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Macular Degeneration

Macular degeneration is the leading cause of vision loss in individuals over the age of 50. It develops with age, and is also called age-related macular degeneration.

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What is Macular Degeneration?

Macular Degeneration is a chronic eye disease. It results from the deterioration of tissue in the macula. The macula is an area of the retina that is responsible for central vision. Macular degeneration affects central vision as opposed to peripheral vision. For this reason, it does not cause complete vision loss. It can, however, cause severe vision loss and although it can't be cured or reversed, early detection is critical for effective treatment.

Clear central vision is necessary for many tasks, such as reading, facial recognition and driving. The first symptom of macular degeneration is typically the need for more light when reading. Images appear distorted or bent, and the center of the visual field may be impeded by blank spots or dark spots. Macular degeneration can progress rapidly, making early detection that much more important.

The retina is a layer of tissue that sits on the back wall of the eyeball. At the center of the retina lies the macula, which holds rods and cones - light sensitive cells that are essential for central vision. The underlying layer of blood vessels responsible for providing nourishment to rods and cones is called the choroid. On the outermost surface of the retina lies the retinal pigment epithelium (RPE), a layer of tissue that provides a passage for nutrients from the choroid to the retina.

As eyes age, the RPE deteriorates and gets thinner. This negatively impacts the movement of nutrients and leads to the formation of waste deposits. The end result is damage to the rods and cones present in the macula, causing blurred or distorted vision.

There are two types of Macular Degeneration

1) Dry Macular Degeneration

This is the most commmon form of macular degeneration. Typically, dry macular degeneration affects both eyes, but often begins in one eye. Dry macular degeneration involves the RPE cells, and severely interrupts the normal disposal of waste, causing waste to build up in the RPE and the degeneration of cells in the macula. Dry macular degeneration is brought on by aging, and can result in complete loss of central vision

2) Wet Macular Degeneration

Wet macular degeneration begins with dry macular degeneration, and accounts for up to 15% of all cases of macular degeneration. Cases of wet macular degeneration cause close to 90% of all cases of severe vision loss from either type of macular degeneration.

This form of macular degeneration results from the growth of new blood vessels from the choroid that leak blood or fluid, causing the deterioration of central vision. It is believed that the abnormal growth of blood vessels may be caused by an interruption in the waste disposal system from the cones and rods and the subsequent accumulation of nutrients to the macula.

Wet macular degeneration typically leads to severe and rapid vision loss.

Both types of macular degeneration carry with them their own symptoms.

Dry Macular Degeneration

- Requiring very bright light when reading or doing close detail work
- Finding that printed words appear blurry
- Washed out or dull color perception
- Blind spots in the center of the visual field
- Increased overall blurriness of vision

Wet Macular Degeneration

- Visual distortions
- Blurry spot in central vision
- Decreased central vision

In both forms of macular degeneration, a patient may feel symptoms occurring in only one eye; however, as the condition develops in the other eye, the good eye is able to compensate less for the limitations of the initially affected eye, and overall eyesight is significantly diminished.

Are you at risk?

Although researchers have yet to pinpoint the actual cause of macular degeneration, they do believe that some factors may contribute to a person's susceptibility.

1) Age

Individuals over age 50 are at much higher risk.

2) Sex

Women are more likely than men to be affected by macular degeneration.

3) Race

Asian Americans, American blacks and American Indians are less likely than other groups to develop macular degeneration.

4) Ultraviolet Light Exposure

Long term exposure to intense sunlight and sunlamps can increase the chances of developing macular degeneration.

5) Eye Color

Individuals with light colored eyes are most likely to develop the disease.

6) Nutrients

Low levels of minerals and vitamins such as A, C, and E may increase the risk of developing the disease.

7) Cardiovascular Disease

Patients who have experienced heart attack, stroke, angina or circulatory problems may be at increased risk.

8) Smoking

Smokers are up to 3 times as likely as non-smokers to develop macular degeneration.

Diagnosing Macular Degeneration

When a doctor conducts a complete eye exam, he or she will examine the macula. The presence of mottled pigmentation in the macula is a sign of macular degeneration. A comprehensive eye exam will include an examination for central vision, typically using an Amsler grid. A doctor can determine the extent to which macular damage is present by examining where on the grid visual distortion occurs.

Fluorescein Angiography can be used to assess the extent of damage from macular degeneration. Fluorescent dye is injected into a leg or arm and photographs are taken as the dye passes through the blood vessels in the retina and choroid. This test shows the presence of abnormal blood vessels in the macula and detects changes in macular pigmentation.

The damage caused by macular degeneration cannot be reversed; however, as with so many other eye diseases, early prevention and treatment are critical.


Resources: Get detailed information from the Macular Degeneration Foundation. Learn about treatment options for macular degeneration.

 

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